RESUMO
Nodular lichen myxoedematosus is a localised form of lichen myxoedematosus, a chronic idiopathic cutaneous mucinosis of known aetiology. Ustekinumab is a human interleukin-12/23 monoclonal antibody that could directly or indirectly increase mucin production. Herein, we report for the first time a case of nodular lichen myxoedematosus associated with ustekinumab.
Assuntos
Erupção por Droga/etiologia , Fármacos Gastrointestinais/efeitos adversos , Erupções Liquenoides/induzido quimicamente , Mucinoses/induzido quimicamente , Ustekinumab/efeitos adversos , Adulto , Doença de Crohn/tratamento farmacológico , Erupção por Droga/patologia , Humanos , Erupções Liquenoides/patologia , Masculino , Mucinoses/patologiaRESUMO
BACKGROUND: The assessment of discrepancies between surgical and histopathological measurements of specimens is important in order to avoid repeat surgery and unnecessary follow-ups. OBJECTIVES: The objective of this study was to quantify the degree, time and influential factors of shrinkage of cutaneous surgical specimens. METHODS: Data of 111 patients were gathered on age, sex, localization, diagnosis and specimen width and length before surgical excision (in vivo), at 5 min postsurgery (ex vivo) and after 24 h of fixation in 10% buffered formalin (postfixation). RESULTS: The length and width were significantly lower in the postfixation vs. in vivo specimens, with a mean shrinkage of 17.0% in the length (p < 0.01) and 9.5% in the width (p < 0.01). 81.8% and 92.3% of the total shrinkage in length and weight was observed between in vivo and ex vivo measurements. No significant differences were observed as a function of sex, age or diagnosis. A greater shrinkage in length between in vivo and postfixation was found in specimens from the trunk. LIMITATIONS: The most of the skin samples were diseased. CONCLUSION: The largest proportion of specimen shrinkage occurred within 5 min of its excision and the shrinkage was greater in specimens from the trunk.
Assuntos
Neoplasias Cutâneas/patologia , Pele/patologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Artefatos , Pesos e Medidas Corporais , Estudos Transversais , Procedimentos Cirúrgicos Dermatológicos/métodos , Feminino , Fixadores , Formaldeído , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias Cutâneas/cirurgia , Manejo de Espécimes/métodos , Fixação de Tecidos/métodosAssuntos
Humanos , Feminino , Pessoa de Meia-Idade , Miíase/complicações , Miíase/tratamento farmacológico , Pioderma Gangrenoso/complicações , Pioderma Gangrenoso/diagnóstico , Pioderma Gangrenoso/tratamento farmacológico , Dípteros , Dípteros/parasitologia , Prednisona/uso terapêutico , Corticosteroides/uso terapêutico , Imunossupressores/uso terapêutico , Dermatopatias/complicações , Dermatopatias/tratamento farmacológico , Dermatopatias/parasitologiaRESUMO
No disponible
Assuntos
Humanos , Feminino , Pessoa de Meia-Idade , Leishmania/isolamento & purificação , Leishmaniose Cutânea/diagnóstico , Doenças Nasais/etiologia , Infecções Oportunistas/etiologia , Úlcera Cutânea/etiologia , Doença Crônica , Diagnóstico Diferencial , Granuloma Letal da Linha Média/diagnóstico , Hospedeiro Imunocomprometido , Leishmaniose Cutânea/etiologia , Leishmaniose Cutânea/parasitologia , Lúpus Eritematoso Sistêmico/complicações , Linfoma Cutâneo de Células T/diagnóstico , Ácido Micofenólico/análogos & derivados , Ácido Micofenólico/uso terapêutico , Doenças Nasais/parasitologia , Infecções Oportunistas/parasitologia , Prednisona/uso terapêutico , Síndrome de Sjogren/complicações , Úlcera Cutânea/parasitologiaRESUMO
BACKGROUND: The prognostic benefit of health care service provision and delivery policies for patients with malignant melanoma (MM) is not yet clear. OBJECTIVE: To analyze the role of health care provision determinants in the initial prognosis of MM. METHODS: A multicenter cross-sectional study was conducted at 14 public hospitals and recruited 3550 patients with MM between 2000 and 2009. The study variables were analyzed using univariate and multivariate models to identify their role in the variations observed. RESULTS: In a 10-year period, the number of patients with MM increased by 78.54%, with primary in situ MM (Tis) or MMs with a Breslow thickness <1 mm (T1) representing 51.72% of the total number of MMs in 2000, increasing to 62.23% by the end of the study period (P = .005). Among the variables that explained the variation in MM frequency the year of diagnosis after 2004 (univariate odds ratio [OR], 1.43 [P < .001]; multivariate OR, 1.36 [P = .005]) and diagnosis in centers with specific fast-track referral systems (univariate OR, 1.24 [P = .01]; multivariate OR, 1.59 [P = .025]) were shown to explain the increasing frequency of Tis-T1 MM. LIMITATIONS: The primary potential limitation of this study is its retrospective nature. CONCLUSION: Health care provision policies and interventions aimed at improving accessibility to specialized care appear to explain the increasing frequency of Tis-T1 MM.
Assuntos
Acesso aos Serviços de Saúde , Melanoma/epidemiologia , Neoplasias Cutâneas/epidemiologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Carcinoma in Situ/epidemiologia , Carcinoma in Situ/patologia , Criança , Pré-Escolar , Estudos Transversais , Feminino , Humanos , Lactente , Masculino , Melanoma/patologia , Pessoa de Meia-Idade , Prevenção Primária , Prognóstico , Estudos Retrospectivos , Neoplasias Cutâneas/patologia , Espanha/epidemiologia , Adulto JovemAssuntos
Leishmania/isolamento & purificação , Leishmaniose Cutânea/diagnóstico , Doenças Nasais/etiologia , Infecções Oportunistas/etiologia , Úlcera Cutânea/etiologia , Doença Crônica , Diagnóstico Diferencial , Feminino , Granuloma Letal da Linha Média/diagnóstico , Humanos , Hospedeiro Imunocomprometido , Leishmaniose Cutânea/etiologia , Leishmaniose Cutânea/parasitologia , Lúpus Eritematoso Sistêmico/complicações , Linfoma Cutâneo de Células T/diagnóstico , Pessoa de Meia-Idade , Ácido Micofenólico/análogos & derivados , Ácido Micofenólico/uso terapêutico , Doenças Nasais/parasitologia , Infecções Oportunistas/parasitologia , Prednisona/uso terapêutico , Síndrome de Sjogren/complicações , Úlcera Cutânea/parasitologiaRESUMO
BACKGROUND: Lichen planopilaris (LPP) is a rare variant of cutaneous lichen planus that preferentially involves hair follicles. OBSERVATION: We describe the case of an 87-year-old woman with cicatricial alopecia due to lichen planopilaris. The diagnosis was based on clinical evaluation, histopathology and trichoscopy. Squamous cell carcinoma developed within the hairless area after 18 years of evolution. CONCLUSION: It is necessary to consider the association between lichen planopilaris and squamous cell carcinoma and to ensure a close follow-up of LPP patients, especially when there is a long history of the disease or new a lesion develops, which does not correspond clinically or in trichoscopy to lichen planopilaris.
RESUMO
We present the uncommon case of a subcutaneous fascia-based extramedullary plasmacytoma in the leg, which was confirmed by the pathology report and followed up until its remission. We report the differential diagnosis with other more common soft tissue masses. Imaging findings are nonspecific but are important to determine the tumour extension and to plan the biopsy.
RESUMO
Presentamos dos casos de milium coloide del adulto en un varón y una mujer de 47 años de edad con una historia de intensa exposición a radiación ultravioleta por razones de índole profesional. Es una enfermedad de depósito, de la que recordamos su clínica, diagnóstico diferencial, histología y tratamiento. Recordamos las características diferenciales entre las distintas variantes de esta entidad (AU)
